After second pill, weve notice he has been a bit down for a couple days. Gave Simparica to my dog yesterday. Another difference is flavor. I've sent this thread and loads of other information to my vet and zoetis. for flea and ticks? He has been drinking more water then usual. Sometimes I think he is either blind or deaf. My personal dog has had no issues at all, and she's been on it for nearly two years. Has anyone experienced cardiac issues while under anesthesia on this medication? My dog is having seizures. I removed it immediately She just tested positive for Lyme's. Most of us dog parents use some form of heartworm prevention for our dogs. He had a problem with severe biting a few months back and Vet said he most likely allergic to fleas (bites). However, your dog must have a history of negative test results for these diseases. The same thing possibly is happening to my 9 month old Boxador. After 9 days he began vomitting, even water, and mouth chattering like he was scared. Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. Losing my Dolly devastated me and I wanted to warn others about Simparica but I got sick. Never saw tremors before. He eats and drinks fine but looks like we havent fed him in days. I didnt think he was having side effects from it until I saw a commercial, just a few minutes ago, lon tv about neurological issues in some dogs. Just had my 1 yr old goldendoodle to the vet because he has had 3 seizures in the last month. I even said "I am reading a blog, right now, with pages of stories about this drug and the side effects". We rescued another dog. He is 5 months old. No running or jumping, Continuously wandering around the fence line of the back yard. I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. These are the side effects that were observed: Most common is vomitting Weakness and lethargy Soft stools Loss of appetite Poor dog prob thinks HE did something wrong. He loves the taste of Simparica Trio and it's like a treat for him. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. Hi there, my dog has been taking simparica trio for two months. My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. We have a 3 month old Aussie labradoodle and the breeder warned against oral flea meds. She has NEVER done that before. It started working on him right away, Diarrhea. Moreover, the safe use of this product has not been evaluated in breeding, pregnant or lactating dogs. The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, Im very worried and concerned. Will it get worse Will he get better? In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. corgi lying in grass next to woman's feet. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. By June 7th, she had a rash over most of her body, itching and biting herself to bloody raw spots. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. Sunday, he was lethargic and refused to eat. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. We are already close to $2000 in Vet bills not counting the poison we bought her. If so how long did it take? Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. I feel horrible for listening to the vet without researching this on my own. Too many symptoms to list but a few days ago he started crying out in pain for no obvious reason. She had right sided weakness, with right sided neglect( the inability to process stimuli with impaired spatial recognition ). Then a week later 2 more just 24 hours apart then a little over w week later she had 3 in 24 hours. 5 hours after the dose she's home resting. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. He was a normal dog before the medicine Simpatico Trio . Then she lost control of her legs and couldn't walk or stand. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. Lost all appetite. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. Vet said if she vomits bring her in. His neck felt swollen and he was panting heavily gasping for air. It is the flea and tick component that is the problem. UPDATE We had one normal day on Friday. She keeps running through the house as though looking for something. And how do we get the word out to everyone? Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. I will never give another dose to him! AVOID THIS PILL! For me, Simparica Trio has made parasite control effective and easyI just give her one chewable tablet each month. Shes now in the Er. She has been taking Trifexis for years with no problem. I started thinking about his history. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. If it was due to the Simparica, then it would expected to be resolved within a day or two. The whole packet is going in the bin !! I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . Omg my girl goes threw incredible itching this has lead to us takeing her to the vet because she gets infected from scratching herself to death. It is also labeled for the treatment and prevention of the Gulf Coast tick, American dog tick, black-legged tick, lone star tick, and brown dog tick. . Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. I'm more concerned about fleas and heartworms and Trifexis is just fine for that. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. Head down, facing the wall, tremors, lethargic, and she can't seem to see well. If she comes out of this I will return to heartworm pills and topical flea and tick meds. That trip cost $400 and the result was he needed Simparica flea treatment. Our vet pushed this new drug for this tick season claiming the drug we used previously they had 11 dogs in the previous year were diagnosed with Lyme disease and they no longer had confidence in that drug. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. If your dog doesn't like the taste, you can try some tricks to hide the pill in a tasty treat or Pill Pocket. Billy Boy is a 9 week old Daisy Dog. (My first warning sign right there). He was vomiting, had diarrhea, urinating constantly and the very scary part were the uncontrollable tremors. Will this ever get better as the med wears down? This time he is having seizures. I just started my 80 pound pit on this same medication yesterday. He has been very lethargic, he was an extremely playful pup. I gave this to my 8 yr old chihuahua and a couple days later he started having seizures. Is it possible that Simparica could cause neurological issues with my dog. This is not at all his behavior. At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? (145 Reviews) $15.50 - $31.09. Hello to everyone and I am so sorry we had to meet under these circumstances. My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. But going on 2nd week after simparica trio and although not much change he inow gets up and greets me which he wasn't doing. My 12 yr-old Chihuahua mix is losing his hair right above his nose. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Hi, how long it took for the diarrhea to go away. Poor baby has had vomiting and diarrhoea ever since. It has been one week and she has been acting very anxious since. Read the package insert and it does list tremors and seizures as a side effect. Gave this flea medicine today and by 10 pm toy poodle having siesures every 3-10 seconds. I wish I would have read these comments first. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. The vet office called simparica hotline to find out if it was safe to give her another one. All the swelling went down immediately and the itching went away too. Saving money sounds great, right? We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. I don't want another animal harmed by this stuff, one animal is one to many. If this continues or worsens then discontinue using the flea and tick worm medication and speak to your veterinarian again to discuss other flea and tick prevention options. She also started drinking excessively, and peeing in the house. Also vets needs to tell the truth!!! Simparica Trio works to prevent heartworm disease, treat and prevent flea infestations, treat and control tick infestations, and treat and control roundworms and hookworms. He has been resting most of the day so far, thankfully no seizures.. but I promise I will not be giving him the other 2 doses I got from the vet after reading all of the experiences everyone else has had with their animals. This was days ago when I could still get food into him and the result. $37.98 with Subscribe & Save discount. A heartworm test may be necessary in about six months (that's how long it takes heartworm larvae to mature enough to show up on a test). Thank all who have posted to bring this subject to light. Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . Coton de Tulear. Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. Now we are waiting for the verdict: whether its an infection in his bladder or stones. I threw him his ball and he actually was interested in it. Never any issues with bravecto so we'll return to that medication. With Entyce she is getting her appetite back and seems a little better. Naturally, I want to make sure that she never has to go through that again. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. But I have decided not to give the replacement pill today. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. I'm hoping the tremors will soon diminish, since she is in great shape otherwise. I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. The more we complain the more chance we have of saving other dogs. Initially I noticed minor tremors and twitching when he slept or was just relaxing. They want $5k to do a spinal tap and MRI. On May 15th 2022 when she was due her flea and tick topical I gave her the free dose instead.Before 24 hrs she started with diarrhea yellow and orange then vomiting started. They would clear up after a round of antibiotics but would return the next month. However, the product has not been evaluated in breeding, pregnant, or lactating dogs. My 3 other poodles unaffected. Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. Anything with tick prevention is in the same class of drugs. Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. Very small sample - many deformities, stillborn. My 11 year old terrier mix has been weak, uncoordinated and pacing up and down the hallway most of the day, sometimes stopping and staring at the wall. Some reports showed the dogs could have simparica seizures. He also had a blood test done and all was normal. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. Keep the medication in the blister packs provided until ready to use in order to protect from moisture and light. I am going to try stopping the medication for a month to see if things improve. On the first day he woke up and peed in my bedroom floor. Nobody knows what causes it or makes one dog recover and another not. He had an MRI and it came out good. Our pick for best oral flea control product for dogs is Simparica TRIO, a chewable tablet that is fast-acting and kills more parasites than any other oral product. Although these products can and have been. Both of them aren't eating like they were. I took him back to the vet and explained my concern that it was from the Simparica Trio and they didn't seem concerned that it was the issue. Reading all these similar cases cant figure out how the hell this crap is still being prescribed. She seems more anxious now and really attached to hubby. If your dog has reactions to this medicine, push fluids! However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. Hope your dog is doing well .my dog had clear neurological changes after taking Simparica trio .his tounge just hangs out of his mouth now and that was never the case prior to Simparica,also has tremors and shakes he never previously experienced.also major weight gain even though no increase in diet .i decided to take my pet off of simparico even though the vet strongly engouraged we remain on it even though i explained the symptoms and changes I noticed in my pet ! Are there any side effects to Simparica Trio? My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. Product Overview. Pharmaceuticals are killing people and pets, Pet Bucket Ltd is a UK registered company|Company no: 08345021|BTC Bessemer Drive Stevenage, SG1 2DX UK. The vet insisted it was not from the Simparica Trio. He has never done this, and when I heard it and woke up he couldn't stop. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. The day after administering drug he had two incapacitating seizures. I will keep a close eye on him and hopefully nothing else come about, we will NEVER take this medication again! But now I'm almost convinced that they could have been seizures, and I just pray that they weren't, and pray that he doesn't have to experience anymore troubles. She didn't make it to the next day and died overnight. She had what seemed like a seizure 6 hours after ingesting this product--she was lying in her crate, she peed while lying down, and she vomited, then began rocking back and forth--and now I am terrified for her (it's Saturday, nearly midnight, so tomorrow is Sunday and everything is closed). He has all the symptoms Eveyone is describing. 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