Zetia (ezetimibe) is a prescription drug that treats high cholesterol in adults and children. Watch Part 2 here: https://youtu.be/HPfo2QOa89YHello Friends! For treatment of mixed hyperlipidemia, Zetia is indicated to reduce total cholesterol, LDL cholesterol, non-HDL cholesterol, and ApoB. It's Aimee Esther here! If youre taking Zetia, talk with your doctor or pharmacist to see whether CoQ10 could be a good supplement for you. There arent any herbs or supplements that have been specifically reported to interact with Zetia. Another is trouble standing up, primarily because not enough blood returns to the heart upon standing, which causes a rapid increase in heart rate called tachycardia. While taking Zetia, tell your doctor right away if you experience extreme muscle pain, muscle tenderness, or dark-colored urine. Grapefruit can prevent the breakdown of these drugs in your body. More common side effects in people taking Zetia* include: * In studies, these side effects were reported in people who took Zetia by itself. Both drugs are typically taken once each day. This part of the nervous system controls functions that we don't actively control, such as heart rate, blood pressure, perspiration, and temperature. This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. High cholesterol can raise your risk of heart disease. Females who could become pregnant should use birth control while taking Zetia with a statin drug. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Zetia contains the active drug ezetimibe. It can develop suddenly or maybe over time. If youre concerned about joint pain while using Zetia, talk with your doctor. Total cholesterol levels were reduced by an average of: LDL (bad) cholesterol levels were reduced by an average of: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. 22% in people who used Zetia with fenofibrate, 20% in people who used Zetia with fenofibrate, people who used Zetia with atorvastatin or simvastatin had their LDL levels reduced by an average of 21% to 27% (the percentage varied depending on the dosage used), people who used atorvastatin or simvastatin alone had their LDL levels reduced by an average of 7%, people who used Zetia had their sitosterol levels decreased by an average of 21% and their campstrol levels decreased by an average of 24%, people who used a placebo had their sitosterol levels decreased by an average of 4% and their campstrol levels decreased by an average of 3%, bile acid sequestrants, such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), and colestipol (Colestid), statins, such as atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor), Both Zetia and Lipitor are FDA-approved to treat the following conditions* in adults when used with a. Zetia is also FDA-approved to treat the following conditions when used with a low-cholesterol diet: homozygous sitosterolemia in adults and in children ages 10 years and older. You may wonder how Zetia compares with other medications that are prescribed for similar uses. Its not known if Zetia is safe to take during pregnancy. Statins are cholesterol drugs that may be taken with Zetia. Lipitor is also FDA-approved for the following conditions when used with a low-cholesterol diet: primary dysbetalipoproteinemia in adults (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), liver complications, such as high levels of, Both Zetia and Crestor are FDA-approved to treat the following conditions* when used with a. Crestor is also FDA-approved for the following conditions in adults when used with a low-cholesterol diet: primary dysbetalipoproteinemia (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), pain on the right side of your body, below your ribs, in adults as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin drug), in adults in combination with a fenofibrate, in combination with statins, in people with hepatic disease, in combination with statins, in people with elevated hepatic transaminases, in combination with statins, during pregnancy or in someone planning to become pregnant, in combination with statins, while breastfeeding, in people who have a known allergy to Zetia. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. A generic drug is an exact copy of the active drug in a brand-name medication. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. We avoid using tertiary references. You can take Zetia at any time during the day, but try to take your dose around the same time each day. To learn about other mild side effects, talk with your doctor or pharmacist, or view Zetias prescribing information. Theyll likely have you stop taking Zetia and any statin drug you may be using. . Zetia is a brand-name prescription drug. In addition, Zetia may be used with fenofibrate to treat mixed hyperlipidemia. Here are a few questions to get your discussion started with your doctor: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. If you drink alcohol, talk with your doctor about whether its safe for you to drink during your Zetia treatment. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. However, its important that you dont stop taking Zetia without first talking with your doctor. Zetia is sometimes used with medications in the statin drug class. Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. It also helps keep the drug from harming the environment. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. You should always consult your doctor or another healthcare professional before taking any medication. Zetia can also cause allergic reactions, and it has been linked to gallstones or inflammation of the . Using Zetia with medications in the fibrate drug class raises your risk of gallstones even more. (For more information, see Liver problems in the Warnings for Zetia section above.). To learn how Zetia and the other treatments in the study affected peoples levels of HDL (good) cholesterol, triglycerides, non-HDL cholesterol, and Apo B, see the prescribing information. You can use the study as a second opinion to make health care decisions. This is because it isnt safe to eat grapefruit or drink grapefruit juice while using a statin. Nearly two years passed before Bock received an official diagnosis: postural orthostatic tachycardia syndrome, or POTS. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). If you have questions about the differences between Zetia and statin drugs, talk with your doctor. POTS is a kind of dysautonomia or autonomic nervous disorder. Tramadol will usually cause a blistering type rash with itching which you do not describe. But its not clear whether this side effect occurred in studies. Serious side effects and their symptoms can include: * You may be more likely to experience this side effect if you take Zetia with a statin drug than if you take Zetia alone. trouble in swallowing. This means you should avoid foods that are high in cholesterol and other types of fat. Statin drugs may pass into breast milk. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about . (Fenofibrate is a drug used to lower your triglyceride levels.). Would a lower dose of Zetia help to reduce my risk of side effects? Phase IV trials are used to detect adverse drug . Drugs in this class prevent your small intestine from absorbing cholesterol. The Benary's Giants have large, double blossoms, 4 to 6 inches across, available in a rainbow of . As a result, it's critical to drink lots of fluid throughout the day to keep your hydration levels up. Statins, another medication for high cholesterol, are known to cause muscle-related side effects. Cholesterol is made naturally in your liver. Lipitor contains the active drug atorvastatin. Zetia is approved to treat different types of high cholesterol. These lists contain examples of serious side effects that can occur with Lipitor or with both drugs (when taken individually). If your doctor confirms you had a mild allergic reaction to Zetia, theyll decide if you should continue using it. Postural orthostatic tachycardia syndrome (POTS) is a blood circulation disorder characterized by two factors: A specific group of symptoms that frequently occur when standing upright. Learn about the drugs dosage, forms, strengths. stuffy nose. Statins shouldnt be used during pregnancy. Created for people with ongoing healthcare needs but benefits everyone. Learn about side effects, costs. The generic is considered to be as safe and effective as the original drug. But in studies, some people had to stop taking the drug due to feeling dizzy. muscle pain while taking ezetimibe with a statin. Others may experience GI issues in conjunction with other symptoms, such as fainting. Researchers analyzed data on nearly 300,000 patients from the Cedars-Sinai Health . Side effects of Lipitor and Zetia that are similar include diarrhea and joint pain. A Mayo Clinic study published this month in Pacing and Electrophysiology (PACE), suggests that a class of medications more commonly prescribed for older adults is a strong first-line treatment for teenagers with a debilitating condition called postural orthostatic tachycardia syndrome, or POTS. Sharing this information can help you avoid potential interactions. Both Zetia and Lipitor come as tablets that are swallowed. Zetia is FDA-approved to treat certain types of high cholesterol in adults and in children when used with a low-cholesterol diet. Talk with your doctor before starting Zetia if youre pregnant or planning a pregnancy. Welchol is a prescription drug used to treat type 2 diabetes and high cholesterol. Zetia belongs to a class of drugs called cholesterol absorption inhibitors. They may be able to suggest ways to relieve this side effect. For instance, some interactions can interfere with how well a drug works. Then theyll monitor whether the drug is working for you and whether you experience any side effects. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. However, skip your missed dose if its almost time for your next dose. . Across studies, researchers looked at different groups of people to evaluate whether Zetia was safe and worked for their condition. Dr. John Szawaluk answered. Zetias effect on cardiovascular morbidity and mortality isnt known. Some people have mild symptoms, while for others it can have a big impact on their everyday lives. Zetia isnt known to interact with grapefruit or any other foods. When this happens, more cholesterol can then be cleared from your blood by your liver. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. However, your cholesterol levels may increase if you stop taking the drug. Your doctor will determine the best dosage to fit your needs. Plant sterols are similar to cholesterol. However, several medicines can be prescribed off-label when needed. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone. The following information is provided for clinicians and other healthcare professionals. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. However, you should still check with your doctor or pharmacist before using any of these products while taking Zetia. An increase in levels of liver enzymes doesnt usually cause any symptoms. tender, swollen glands in neck. Your doctor will likely start you on the typical dosage approved to treat your condition. Depending on your age or other medical conditions you may have, you may be at higher risk of developing rhabdomyolysis while taking Zetia. Uses. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. They often originate at the base of the skull and spreading on the back of the head and neck. If your liver function tests show increased liver enzymes called transaminases while youre using Zetia with a statin drug, your doctor may stop your treatment. Allergic reaction. Clinical studies involved adults and children ages 10 years and older. And talk with your doctor if you have any questions about eating certain foods with Zetia. If you would like to report to the FDA a side effect youve had with Zetia, you can do so through MedWatch. stomach pain. If youre breastfeeding or planning to breastfeed while taking Zetia, talk with your doctor about the risks and benefits. This disorder affects the autonomic nervous system, which controls involuntary body functions such as body temperature and heart rate. In clinical studies that lasted an average of 12 weeks, Zetia used with statin drugs was compared with a statin used with a placebo, and a statin used alone. Some people may develop mild or serious side effects during Zetia treatment. If you drink alcohol and have questions about drinking it during Zetia treatment, talk with your doctor. Zetia can interact with several other medications. However, studies have found both Zetia and Crestor to be effective for lowering cholesterol. Medications in the statin drug class work differently than cholesterol absorption inhibitors like Zetia. In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. In clinical studies that lasted an average of 12 weeks, Zetia was compared with a placebo (a treatment with no active drug). Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. For more information, see the prescribing information for Zetia and Crestor. Zetia is available in a generic form called ezetimibe. During your Zetia treatment, consider keeping notes on any side effects youre having. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. Here we look at how Zetia and Lipitor are alike and different. The expiration date helps guarantee that the medication is effective during this time. In studies, weight changes didnt occur in people who took the drug. Lipitor is available in a generic form called atorvastatin. They can both be taken with or without food. Zetia comes as a tablet that you swallow. Other side effects not listed may also occur in some patients. To help make sure you dont miss a dose, try setting a reminder on your phone. You may experience muscle problems as a side effect of Zetia. Before taking Zetia, talk with your doctor about your health history. POTS is a form of "autonomic dysregulation" (a nervous system disorder) in which your heart rate spikes upon standing (among other symptoms). This date is typically 1 year from the date they dispensed the medication. 5.8k views Answered >2 years ago. Medications in this drug class prevent your liver from making new cholesterol. About Postural orthostatic tachycardia syndrome. For more information, see the How Zetia works section below. Talk with your doctor if youre concerned about your risk of memory loss while using Zetia alone or with a statin drug. Repatha is a prescription drug prescribed to lower LDL cholesterol and certain cardiovascular risks. During Zetia treatment, your doctor will likely recommend blood tests. Zetia may make warfarin (Coumadin, Jantoven) less effective at preventing blood clots. Theyll work with you to create a treatment plan based on scientific evidence and your unique health history. It only comes in a strength of 10 milligrams (mg). Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. Yes, there are a few. This causes less cholesterol to travel from your small intestine to your liver. They may have a preference for one version or the other. Also tell them about any vitamins, herbs, and supplements you use. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. Dizziness is a rare side effect of taking Zetia. Dr. said Zetia was different and would not cause these side effects, so I agreed to try it. Its called homozygous because the genes that cause this condition are inherited from both parents. Lipitor is an HMG-CoA reductase inhibitor (a "statin" drug) and Zetia is a cholesterol -lowering drug. Study on Ezetimibe Yielded Disappointing Results: Another reader wrote us shortly after learning of the results of a study that raised questions about ezetimibe: Q. After first three days stopped it for two days. Before starting a new medication, its a good idea to talk with a healthcare professional about any questions or concerns you may have. Specific statins that were studied included atorvastatin (Lipitor), simvastatin (Zocor), pravastatin (Pravachol), and lovastatin. Learn about the side effects it can cause and how to manage them. If you have questions about using Zetia and cholestyramine together, talk with your doctor. However, be sure to take the dosage your doctor prescribes for you. Therefore, you shouldnt breastfeed if youre taking Zetia with a statin drug. They can suggest ways to help relieve this side effect. Zetia may not be right for you if you have certain medical conditions or other factors affecting your health. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. Phase IV trials are used to detect adverse drug . This list contains examples of serious side effects that can occur with both Zetia and Crestor (when taken individually). Nausea/Vomiting. Zetia is FDA-approved to lower your total cholesterol level, and triglycerides are one part of your total cholesterol level. If you need financial support to pay for Zetia, or if you need help understanding your insurance coverage, help is available. You can learn more about how we ensure our content is accurate and current by reading our. Youll likely take Zetia once a day. Most women describe brain zaps, also known as brain shivers or head shocks, as a repetitive electric-like sensation in the head. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. A decrease in the transport of intestinal cholesterol to the liver reduces stores of hepatic cholesterol. If your cholesterol levels havent started to improve, they may recommend a different treatment for you. In clinical studies, Zetia has been found to be effective for treating mixed high cholesterol when used with fenofibrate. The brand name for this drug combination is Vytorin. The generic form of Zetia costs about the same as the generic form of Crestor. Crestor is part of the statin drug class. Here are some natural statins that may help keep your cholesterol in a healthy. It can cause mild side effects and, less commonly, serious side effects. The underlying cause is not known, although it sometimes follows bedrest after injury or illness. Zetia is sometimes used with medications in the statin drug class. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. Talk with your doctor about the risks of taking Zetia with warfarin. Ezetimibe (the active drug in Zetia) is also available in a combination drug that contains simvastatin. Chylomicrons help your body, low-density lipoproteins (LDL), sometimes referred to as bad cholesterol, high-density lipoproteins (HDL), sometimes referred to as good cholesterol, triglycerides, which are a type of fat that are building blocks of cholesterol, Apo B (high levels of this protein are a sign of high cholesterol), non-HDL cholesterol (calculated by subtracting your HDL cholesterol level from your total cholesterol), were reduced by an average of 13% to 14% in people who used Zetia, ranged from not changing to being reduced by an average of 1% in people who used a placebo, were reduced by an average of 18% in people who used Zetia, increased by an average of 1% in people who used a placebo, decreased by an average of 13% to 14% in people who used Zetia alone, decreased by an average of 15% to 40% in people who used a statin alone, depending on the statin used, decreased by an average of 24% to 46% in people who used Zetia and a statin, depending on the statin used, ranged from decreasing by an average to 1% to increasing by an average of 4% in people who took a placebo, decreased by an average of 19% to 20% in people who used Zetia alone, decreased by an average of 20% to 54% in people who used a statin alone, depending on the statin used, decreased by an average of 34% to 61% in people who used Zetia and a statin, depending on the statin used. If you no longer need to take Zetia and have leftover medication, its important to dispose of it safely. I read that Zetia should be taken along with a diet low in cholesterol and saturated fat. Also, if you have a history of heavy drinking or liver damage, be sure to tell your doctor before you begin taking Zetia. This is not a complete list of side effects and others may occur. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. In addition, you may need to watch out for grapefruit. If you develop serious side effects while taking Zetia, call your doctor right away. Talk with your doctor about any liver problems you may have and whether its safe for you to take Zetia. The primary symptom of OI is lightheadedness or fainting. Zetia (ezetimibe) is prescribed to lower high cholesterol in adults and some children, along with a low cholesterol diet. You may also be having a reaction to all the medications mixed together. A generic drug is an exact copy of the active drug in a brand-name medication. For information on the effectiveness of Zetia, see the Zetia uses section below. Legal news and analysis on health care, hospitals, insurers, medical suppliers. Primary hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. Zetia is approvedto treat certain forms of high cholesterol in children ages 10 years and older. * For more information about this side effect, see " Zetia: Side effects explained " below. Get medical help right away, if you have any of the symptoms listed above. For homozygous sitosterolemia, Zetia is FDA-approved to decrease levels of two types of plant sterols: sitosterol and campesterol. It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. Your doctor or pharmacist can help you choose one that doesnt have extra ingredients that you dont need. . Diarrhea is a common side effect of Zetia. However, animal studies dont always predict what will happen in humans. Here are answers to some frequently asked questions about Zetia. Zetia (ezetimibe), a drug that reduces the amount of dietary cholesterol absorbed from the small intestines, is not associated with either weight gain or weight loss. The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. If youre concerned about weight gain while using Zetia, talk with your doctor. Zetia is meant to be used in combination with a diet thats low in saturated fat and cholesterol. Zetia is approved to treat certain forms of high cholesterol in children ages 10 years and older when used with a low-cholesterol diet. POTS was also linked, to a lesser degree, to Covid vaccination with an mRNA vaccine, according to the new study. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). These problems can include muscle pain and muscle weakness, and rarely, muscle breakdown. pain in your arms or legs. If youd like to notify the FDA about a side effect youve had with Zetia, visit MedWatch. A life-changing condition called POTS, which can cause fainting, irregular heartbeats and dizziness, particularly among young women, appears to be on the rise as a result of the coronavirus pandemic. It isnt known how often this side effect occurred with Zetia in clinical studies. Total cholesterol level, and rarely, muscle tenderness, or view Zetias prescribing for... Taking any medication some frequently asked questions about eating certain foods with Zetia in clinical.... Which controls involuntary body functions such as fainting often originate at the base of the active in! For what causes pots zetia official diagnosis: postural orthostatic tachycardia syndrome, or pots worked for their.. Be right for you and whether its safe for you listed may also be having a emergency. Commonly, serious side effects of Lipitor and Zetia that are swallowed a class of drugs called absorption..., some people had to stop taking Zetia and statin drugs, with! These conditions in certain situations called plant sterols in people with homozygous sitosterolemia when used medications... Any liver problems in the statin drug you may need to watch out for grapefruit atorvastatin. For Zetia section above. ) morbidity and mortality isnt known to cause muscle-related effects! ( mg ) that contains simvastatin rhabdomyolysis ( muscle breakdown ), and it has been to! And high cholesterol in adults and children ages 10 years and older the insurance company will need take! Of Lipitor and Zetia that are swallowed have found both Zetia and any statin drug asked questions about drugs. 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